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- Acute myocardial infarction in a 22-year-old world class weight lifter utilizing anabolic steroids.
- Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in males with established coronary artery disease .
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Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which can contribute to abnormal vessel reactivity. However, testosterone in physiologic doses could even be beneficial in sufferers with angina , have higher ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood flow in men with established coronary artery disease .
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Unfortunately, the information on the use of high dose anabolic steroids in humans are primarily supplied as case reviews or small studies that lack sufficient management teams. In addition, the data out there within the literature does not account for the steroid kind or dose, as neither may be known. Patients also could also be taking concomitant stimulants, such as ephedra, which may confound knowledge and the potential for opposed events. It is in all probability going that the frequency of cardiac events is underreported in the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which include greater than 30 natural and artificial derivatives of testosterone, might cause a large spectrum of medical sequalae.
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac risk elements utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, likely secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the right coronary artery. Physicians and sufferers ought to pay consideration to the medical consequences of anabolic steroid abuse.
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